Endocrine Abstracts

Introduction: Interleukine-4 (IL-4) a T-helper type 2 cytokine (Th2), has been implicated in the pathogenesis of autoimmune thyroid diseases (AITD). However, the role of IL-4 in Hashimoto’s thyroiditis (HT) pathogenesis remains controversial. In this study, we investigated whether a constitutive IL-4 overexpression in the thyroid tissue (Thyr-IL4) could influence the development of thyroiditis in resistant (C57BL/6) or susceptible (NOD.H2h4) mouse strains.<...